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Anti-Doping Agency, many of these are not approved for human use, are often sold from unregulated sources, and can lead to positive drug tests

Although increased replicative DNA synthesis leading to increased numbers of hepatocytes can explain the liver enlargement induced by 1,2-bis(2-pyridyl)ethylene, an explanation for the liver enlargement induced by tert-butylated hydroxyanisole was not evident

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Because the pill is taken daily and requires higher doses to be absorbed, some patients find it harder to tolerate or harder to take consistently